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www.11gvb.com_www.11gvb.com-【择押和局】

文章来源:SEO    发布时间:2019-05-27 05:00:29  【字号:      】

www.11gvb.com_www.11gvb.com-【择押和局】About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”

About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”

About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”

About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”About | Our People | Mike Thien, Ph.D.#标题分割#InJanuary1994,withmuchoftheEastCoastburiedinsnow,MSDscientistsinPennsylvaniaconfrontedtheelementstocontinuetheirworkinthelab.TheWashingtonPostlaterdescribedthemas“braveorstupid,”buttheresearchersweremotivatedbysomethingbig:thepotentialforabreakthroughdiscoveryinthefightagainstHIV.Sixyearsearlier,MSDhadbeenthefirsttoprovethatinhibitingtheHIVproteaseenzymecouldpreventthevirusfromreplicating.Thatdiscovery,however,wasonlythebeginning.Shortlythereafter,theresearchersandscientistsenduredanumberofdiscouragingsetbacks,includingthefailureofapromisingcompoundandthedeathofoneofourleadresearchersintheLockerbiebombingofPanAmflight103.Butourcolleagueswouldnotbedeterredintheirsearch.Michael(Mike)Thien,Ph.D.,whocurrentlyheadsupGlobalScience,TechnologyandCommercializationforMSDManufacturingDivision,wasoneofthosescientists.“Wehadagreatsenseofurgencytotheworkthatweweredoing”“Itwasabigchallenge.Theproductitselfwasprobablythemostcomplexchemicalentitythatwehadevermade,”Mikeremembers.“ButwefelteverydaytherealpressureofthefactthattherewerenogoodtherapiesforHIVatthetime.Andsothataddedagreatsenseofurgencytotheworkthatweweredoing.Noonesaidthattheycouldn'tdothisorthat.Noonesaidtheycouldn'tstayafterandworklonger.”Rememberinga‘watershed’momentinhislifeAlltold,MSDinvestedmorethan0million(.3billionintoday’sdollars)intheproject,whichincludedamassiveclinicaltrialinvolvingsome4,800patientsin11countries.Ourcommitmentwasfinallyrewardedin1996,whentheFoodandDrugAdministration(FDA)approvedourtreatmentforHIVinjust42days,thefastestapprovalinFDAhistory.Butbeforethisbreakthrough,Mikeonlyencounteredwhathedescribedas“failures”inhiswork.“Overthecourseofatwoandahalfyearperiod,Iwentfromworkingoneightthingsthatfailedtoonethingthatworked.ButthatonethingthatworkedWell,thatwasawatershedmomentinmylife.”It’ssomethingheencouragesotherscientistsandresearcherstoremember.“Therearen’talotofbusinesseswherewhensomethingentersclinicaltrials,itonlyhasaninepercentchanceofmakingitallthewaythroughtothemarketplace,”hesays.“Whenyou’redoingdevelopmentworkinourbusiness,youaregoinginwiththephilosophythat,yes,you’regoingtogettoworkonalotofgreatthings.Butyou’llbereally,reallyluckyifoneofthemisgoingtothemarketplacetomakeadifference.”Whatisinstoreforthefutureforthisdistinguishedscientist–andMSDAsheentershis27thyearatthecompany,MikecurrentlyrunsthescientificandtechnologyareainmanufacturingatMSD.“Igettodothreethings:Fromamanufacturingperspective,myareaworksonthelastbitsofdevelopmentforprocessesandproductsandpackagingfornewproducts–wegetthemreadytobemanufactured.Thesecondthingisgettingtheseverycomplextechnicalprocessesreadyforthemanufacturingfloor.Theyhavechallengesfromtimetotime.SoIoverseethetechnicalteamstoidentifywhywemightbehavinganissueandhowtofixit.ThelastthingI’mresponsibleforareallofourcapitalassets--allofthebuildingsandfactorieswebuild.”He’sstillasbusyasever,butMikeonlyseesthebrightsideofallofthework.“TherearesomethingsyoucandoworkingforacompanylikeMSDthatyouwouldneverbeabletodoinacademia,whereIwouldneverbeabletodevelopanewoperatingmodelorcomeupwithanewmanufacturingprocess.Iwouldneverbeabletosaythatmyworkcontributedtohelpthelivesofhundredsofthousandsofpeople.Thosearethethingsyoudon’tgettosayasanacademician,”henotes.“ButatacompanylikeMSD,yougettosaythemwithpride.”

精神的圣地 | 中国国家地理网#标题分割#这真是一块圣地,近百年来,这里成长了中国数代最优秀的学者。丰博的学识、闪光的才智、庄严无畏的独立思想,这一切又与耿介不阿的人格操守以及勇锐的抗争精神相结合,构成了一种特殊的精神魅力。民主与科学已经成为这块圣地不朽的魂灵。——谢冕我静静地穿行在燕南园里,葱茏的绿色掩映着西式的两层小楼和中式的院落。园子的整个布局略呈正方形,初看就像一个普通的居民小区。与北京大学校园里其它地方的车水马龙相比,这园子显得寂寥了许多。进入燕南园,我有一种恍若隔世的感觉。温文尔雅的洪煨莲先生曾在这里切磋学问,冰清玉洁的谢婉莹先生曾在这里写下了《南归》,笑容团团的汤用彤先生曾在这里踱步,勇锐不阿的马寅初校长曾在这里坚持要辩论他的《新人口论》,刚正耿直的翦伯赞先生曾在这里徘徊,美髯飘飘的冯友兰先生曾在这里编订《中国哲学史新编》,朱光潜先生曾在这里进行美学思考……每一次在这里漫步,我都会用心追寻那一丝一缕的历史记忆。燕南园的历史并不长,但是它所经历的曲折和顺畅与中国现代知识分子走过的道路紧紧相联。中国现代知识分子的命运缔造了燕南园。1919年,由美国教会在清末创办的北京汇文大学、通州协和大学和华北协和女子大学三校合并成立了一所新的大学,聘请正在南京金陵神学院任教的“中国通”司徒雷登博士(Dr.JohnLeightonStuart)任校长,新大学被命名为“燕京大学”。精神的圣地 | 中国国家地理网#标题分割#这真是一块圣地,近百年来,这里成长了中国数代最优秀的学者。丰博的学识、闪光的才智、庄严无畏的独立思想,这一切又与耿介不阿的人格操守以及勇锐的抗争精神相结合,构成了一种特殊的精神魅力。民主与科学已经成为这块圣地不朽的魂灵。——谢冕我静静地穿行在燕南园里,葱茏的绿色掩映着西式的两层小楼和中式的院落。园子的整个布局略呈正方形,初看就像一个普通的居民小区。与北京大学校园里其它地方的车水马龙相比,这园子显得寂寥了许多。进入燕南园,我有一种恍若隔世的感觉。温文尔雅的洪煨莲先生曾在这里切磋学问,冰清玉洁的谢婉莹先生曾在这里写下了《南归》,笑容团团的汤用彤先生曾在这里踱步,勇锐不阿的马寅初校长曾在这里坚持要辩论他的《新人口论》,刚正耿直的翦伯赞先生曾在这里徘徊,美髯飘飘的冯友兰先生曾在这里编订《中国哲学史新编》,朱光潜先生曾在这里进行美学思考……每一次在这里漫步,我都会用心追寻那一丝一缕的历史记忆。燕南园的历史并不长,但是它所经历的曲折和顺畅与中国现代知识分子走过的道路紧紧相联。中国现代知识分子的命运缔造了燕南园。1919年,由美国教会在清末创办的北京汇文大学、通州协和大学和华北协和女子大学三校合并成立了一所新的大学,聘请正在南京金陵神学院任教的“中国通”司徒雷登博士(Dr.JohnLeightonStuart)任校长,新大学被命名为“燕京大学”。




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